Thật vậy, đường kính của chuỗi xoắn DNA chỉ là 20, trong khi sợi nhiễm sắc chất quan sát dưới kính hiển vi điện tử có đường kính 100, đôi khi đạt 300. Điều này chứng tỏ phân tử DNA tham gia trong việc hình thành những cấu trúc phức tạp hơn (hình 2.6). Sợi có đường kính 100 là một chuỗi nhiều nucleosome. Đó là những cấu trúc hình thành từ một sợi DNA quấn quanh một lõi gồm 8 phân tử histon. Sợi 100 này được tổ chức thành cấu trúc phức tạp hơn là sợi có đường kính 300. Trong nhân tế bào, các sợi vừa kể trên kết hợp chặt chẽ với nhiều protein khác nhau và cả với các RNA tạo hành nhiễm sắc chất, mức độ tổ chức cao nhất của DNA.
Phân tử DNA được sắp xếp trên nhiễm sắc thể làm cho chiều dài ngắn lại hơn 50.000 lần.
Các DNA ở eukaryote có đặc điểm khác với DNA prokaryote. Toàn bộ phân tử DNA prokaryote đều mang thông tin mã hóa cho các protein trong khi đó DNA eukaryote bao gồm những trình tự mã hoá (các exon) xen kẽ với những trình tự không mã hoá (intron). Các trình tự mã hoá ở eukaryote chìm ngập trong một khối lớn DNA mà cho đến nay vẫn chưa rõ tác dụng. Tùy theo mức độ hiện diện của chúng trong nhân, các trình tự DNA được chia làm ba loại:
- Các trình tự lặp lại nhiều lần. Ví dụ: ở động vật có vú các trình tự này chiếm 10-15% genome (hệ gene). Đó là những trình tự DNA ngắn (10-200 kb), không mã hoá, thường tập trung ở những vùng chuyên biệt trên nhiễm sắc thể như ở vùng tâm động (trình tự CEN) hay ở đầu các nhiễm sắc thể (trình tự TEL). Chức năng của các trình tự này chưa rõ, có thể chúng tham gia vào quá trình di chuyển DNA trên thoi vô sắc (trình tự CEN) hoặc vào quá trình sao chép toàn vẹn của phần DNA nằm ở đầu mút nhiễm sắc thể (trình tự TEL).
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)
- Các trình tự có số lần lặp lại trung bình. Ví dụ: ở genome người, các trình tự này chiếm 25-40 %. Chúng đa dạng hơn và có kích thước lớn hơn (100-1.000 kb) các trình tự lặp lại nhiều lần. Các trình tự này phân bố trên toàn bộ bộ gen. Chúng có thể là những trình tự không mã hóa mà cũng có thể là những trình tự mã hóa cho rRNA, tRNA và RNA 5S.
- Các trình tự duy nhất: là các gen mã hóa cho các protein, có trình tự đặc trưng cho từng gen.
Một đặc điểm của phân tử DNA có ý nghĩa rất quan trọng được sử dụng vào phương pháp lai phân tử. Đó là khả năng biến tính và hồi tính. Biến tính là hiện tượng hai sợi đơn của phân tử DNA tách rời nhau khi các liên kết hydro giữa các base bổ sung nằm trên hai sợi bị đứt do các tác nhân hóa học (dung dịch kiềm, formamide, urea) hay do tác nhân vật lý (nhiệt). Sau đó, nếu điều chỉnh nhiệt độ và nồng độ muối thích hợp, các sợi đơn có thể bắt cặp trở lại theo nguyên tắc bổ sung, để hình thành phân tử DNA ban đầu, đó là sự hồi tính.
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