28
LA-960
LASER DIFFRACTION
LA-350
LASER DIFFRACTION
SZ-100
DYNAMIC LIGHT SCATTERING
PSA300
IMAGE
ANALYSIS
CAMSIZER P4
IMAGE ANALYSIS
CAMSIZER X2
IMAGE ANALYSIS
ViewSizer 3000
MULTISPECTRAL NANOPARTICLE
TRACKING ANALYSIS
1nm
1µm
1mm
10nm
10nm
0.3nm
0.1µm
0.5µm
20µm
0.8µm
15µm
5mm
8µm
1000µm
1000µm
30mm
8mm
DYNAMIC RANGE OF THE HORIBA
PARTICLE CHARACTERIZATION
SYSTEMS
The decision process may be different if the instrument is being purchased
for a specific application as opposed to a general analytical technique for
many possible samples. For specific application it makes sense to search the
industry literature to determine if a particular technique is favored over others. If
for example the application is liposomes and 90% of all literature
found in this field
is DLS, then the decision is simple. On the other hand, if this is the first particle size
analyzer bought by a company for general purpose use,
then flexibility and a wide
dynamic range should be important factors.
Sometimes the goal to buy a new instrument includes being able to correlate
to existing data. Accomplishing this goal can range from easy to difficult. Just
upgrading from an older to newer model diffraction analyzer could cause a change in
results. The changes originate from many sources including differences in dynamic
range,
advances in algorithms, and mechanic improvements to samplers. Switching
from an existing technique such as sieving to newer techniques like laser diffraction
or dynamic image analysis could also lead to changes in results. Data from sieves
are typically smaller than data from laser diffraction depending on
the shape of the
particles. The less spherical the particle, the greater the difference will likely be. The
CAMSIZER dynamic image analyzer has multiple approaches built into the software
to facilitate data matching with sieves. As a general rule, data can be manipulated to
approach existing results, but understanding this issue during
the selection process
can ease the implementation of a new technique.
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