Table of contents 1 Why is particle size important?
WHEN TO CHOOSE IMAGE ANALYSIS
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| WHEN TO CHOOSE IMAGE ANALYSIS
Many laboratories are now replacing manual microscopy with automated image analysis. While microscopy provides qualitative accuracy and shape information, it requires automated image analysis to inspect the number of particles requited to obtain statistically valid quantitative results. Choosing image analysis is often driven by the desire to generate results that are accurate, sensitive to second populations, contains shape information, and includes images of the particles. Dynamic image analysis is used in both research and QC laboratories for particles ranging from 30µm to 30mm. Static image analysis is typically a research tool for measuring particles in the 0.5 to 1000µm range. Deciding between dynamic or static image analysis is seldom difficult, as the applications are typically better served by one technique or the other, as proven through application development studies. REFERENCES 1 (PAGE 3) ISO 9276-2:2001 : Representation of results of particle size analysis – Part 2: Calculation of average particle sizes/diameters and moments from particle size distributions 2 (PAGE 3, 4) ASTM E 799-03 Standard Practice for Determining Data Criteria and Processing for Liquid Drop Size Analysis 3 (PAGE 3) TN154, Particle Size Result Interpretation: Number vs. Volume Distributions, available at www.horiba.com/us/particle 4 (PAGE 5) ISO 13320-1 Particle size analysis – Laser diffraction methods 5 (PAGE 7) ISO 13322-2 Particle size analysis – Image analysis methods – Part 2: Dynamic image analysis methods 6 (PAGES 8-9, 14) Burgess, J., Duffy, E., Etzler, F., Hickey, A., Particle Size Analysis: AAPS Workshop Report, Cosponsored by the Food and Drug Administration and the United States Pharmacopeia, AAPS Journal 2004; 6 (3) Article 20 (http://www.aapsi.org) 7 (PAGE 10) TN154, Particle Size Result Interpretation: Number vs. Volume Distributions, available at www.horiba.com/us/particle 8 (PAGE 11) TN156, Particle Size Result Interpretation: Under- standing Particle Size Distribution Calculations, avail- able at www.horiba.com/us/particle 9 (PAGE 12) ISO 13320-1 Particle size analysis – Laser diffraction methods 10 (PAGE 12) USP<429> Light Diffraction Measurement of tải về 7.54 Mb. Chia sẻ với bạn bè của bạn:
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