Nguyễn Phương Đại Nguyên2, Nguyễn Tiến Đạt1
1Viện Hóa sinh biển, Viện Hàn lâm Khoa học và Công nghệ Việt Nam,
18-Hoàng Quốc Việt, Cấu Giấy, Hà Nội, Việt Nam
2Bộ môn Sinh học, Khoa Khoa học Tự nhiên và Công nghệ, Trường Đại học Tây Nguyên,
567 Lê Duẩn, Buôn Mê Thuột, Đăk Lăk, Việt Nam
A phytochemical investigation of the methanol extract of Ganoderma lucidum fruiting bodies led to the isolation of ergosterol (1) and ergosterol peroxide (2). Their structures were identified by means of spectroscopic methods including ESI-MS and NMR. Compound 2 showed strong cytotoxicity against EGFR-TKI-resistant human lung cancer A549 and H1975 cell lines at 100 μM. In addition, Compound 2 significantly inhibited the nitric oxide production in LPS-induced RAW264.7 cells. This pape is the first report on the effect of G. lucidum extract, ergosterol and ergosterol peroxide against EGFR-TKI-resistant human lung cancers.
|