Title: Direct Activation of Fission Yeast Adenylyl Cyclase by Heterotrimeric g protein Gpa2



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Shakuyaku-kanzo-to (Shao-Yao-Gan-Cao-Tang) as Treatment of Painful Muscle Cramps in Patients with Lumbar Spinal Stenosis and Its Minimum Effective Dose

T., and Yakushiji, F. 2009. Shakuyaku-kanzo-to induces pseudoaldosteronism characterized by 
hypokalemia, rhabdomyolysis, metabolic alkalosis with respiratory compensation, and increased urinary 
cortisol levels. J Altern Complement Med 15:439-443. 
11. Mauskop, A. 2010. Assessment: symptomatic treatment for muscle cramps (an evidence-based review): 
report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of 
Neurology. Neurology 75:1397; author reply 1398-1399. 
12. Parisi, L., Pierelli, F., Amabile, G., Valente, G., Calandriello, E., Fattapposta, F., Rossi, P., and Serrao, 
M. 2003. Muscular cramps: proposals for a new classification. Acta Neurol Scand 107:176-186. 
13. Tashiro, S. 1996. Pharmacological study of application of Shao-Yao-Gan-Cao-Tang for pain with muscle 
cramps. 41th Annual Meeting of the Japan Society for the Study of Chronic Pain 67. 
14. Tsumura Co. Ltd. Product Catalogue. Tsumura Kampo Medicine Extract Granules for Ethical Use.
15. Walker, B.R., and Edwards, C.R. 1994. Licorice-induced hypertension and syndromes of apparent 
mineralocorticoid excess. Endocrinol Metab Clin North Am 23:359-377. 
16. Yamahara, J., Yamada, T., Kimura, H., Sawada, T., and Fujimura, H. 1982. Biologically active 
principles of crude drugs. II. Anti-allergic principles in "Shoseiryu-To" anti-inflammatory properties of 
paeoniflorin and its derivatives. J Pharmacobiodyn 5:921-929. 
17. Yoshida, M., Kitaoka, H., and Masui, Y. 1995. Effect of Shao-Yao-Gan-Cao-Tang for painful muscle 
cramps in diabetes patients. Therapeutic Neurology 6:529-534. 

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