Trần Thị Phương Thảo2, Trần Văn Sung2
1Đại học Hà Nội, 98 Dương Quảng Hàm, Hà Nội, Việt Nam.
2Viện Hóa học, Viện Hàn lâm Khoa học và Công nghệ Việt Nam (VAST),
18 Hoàng Quốc Việt, Cầu Giấy, Hà Nội, Việt Nam.
3Bảo tàng Thiên nhiên Việt Nam, VAST
From the ethyl acetate extract of leaves and twigs and barks of Nageia wallichiana, collected in Lam Dong province, Vietnam five diterpenoids with the abietane skelett have been isolated. Their structures were elucidated by using combined spectroscopic methods as IR, MS and NMR. The cytotoxic activity of three of five compounds against 8 human cancer cell lines has been evaluated. The nor-diterpene dilactone showed strong activity on all tested cancer cell lines. This is the first report on the chemical constituents and cytotoxic activity of Nageia wallichiana.
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