Vũ Thị Quỳnh Chi1, Phạm Hải Yến1,Nguyễn Xuân Nhiệm1, Dương Thị Dung1,
Đan Thị Thúy Hằng1, Bùi Hữu Tài1, Hoàng Lê Tuấn Anh1, Nguyễn Thị Việt Thanh2, Châu Văn Minh1, Phan Văn Kiệm1
1Viện Hóa sinh biển, Viện Hàn lâm Khoa học và Công nghệ Việt Nam
2Viện Kỹ thuật Hóa học, Đại học Bách Khoa
Four diarylheptanoid metabolites were isolated from the rhizomes of Tacca chantrieri using combined chromatographic methods. Their structures were identified as: 3,5-dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane (1), 3,5-dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside (2), 3,5-dihydroxy-1,7-bis(4-hydroxyphenyl)heptane 3-O-β-D-glucopyranoside (3), and 3,5-dihydroxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-heptane 3-O-β-D-glucopyranoside (4) by spectroscopic analyses and comparison with the data reported in the literature. All compounds were tested for in vitro cytotoxic activity against several human cancer cell lines, including PC3, LNCaP, MDA-MB-231, and HepG2. Compounds 2 and 4 exhibited moderate cytotoxic activities toward three human cancer cell lines PC3, LNCaP, MDA-MB-231 with the IC50 values ranging of 19.1 ÷ 49.3 µM.
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