Effectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (eagle): a randomised controlled trial
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- Điều hướng trang này:
- Ocular characteristics and treatments
- Patient-reported instrument scores
- Table 1 : Baseline characteristics Articles
| Clear-lens extraction
(n=208) Laser peripheral iridotomy (n=211) Missing data Demographics Women 122 (59%) 121 (57%) 0 Chinese origin 62 (30%) 66 (31%) 0 Age (years) 67·0 (61·0–73·0) 67·0 (61·0–73·0) 0 Ocular characteristics and treatments Both eyes suitable for treatment 76 (37%) 76 (36%) 0 Study eye was right eye 110 (53%) 118 (56%) 0 Diagnosis in study eye PAC 80 (38%) 75 (36%) 0 PACG 127 (61%) 136 (64%) 0 Missing 1 (0%) Systemic warfarin use 11 (5%) 7 (3%) 1 Systemic α-agonist use 17 (8%) 25 (12%) 0 Glaucoma topical medication None 83 (40%) 79 (37%) 0 One 71 (34%) 79 (37%) 0 Two 35 (17%) 37 (18%) 0 Three 16 (8%) 10 (5%) 0 Four 2 (1%) 5 (2%) 0 Five 1 (0%) 1 (0%) 0 Glaucoma oral medication 0 2 (1%) 0 IOP (mm Hg) 30·0 (24·0 to 33·0) 30·0 (26·0 to 33·0) 0 Axial length (mm) 22·5 (22·0 to 23·1) 22·7 (22·1 to 23·2) 7 Anterior chamber depth (mm) 2·5 (2·3 to 2·7) 2·5 (2·3 to 2·7) 17 Refractive error (dioptres) 1·6 (0·5 to 3·0) 1·1 (0·0 to 2·4) 39 Visual fi eld mean deviation (dB) –3·0 (–7·0 to –0·8) –3·5 (–7·2 to –1·3) 42 Central corneal thickness (μm) 553·0 (528·0 to 576·0) 551·0 (522·0 to 582·0) 5 Gonioscopy (angle closure º) Closure without indentation 300·0 (270·0 to 360·0) 360·0 (270·0 to 360·0) 23 Synechial closure 90·0 (20·0 to 180·0) 90·0 (10·0 to 180·0) 247 BCVA, ETDRS (N letters) 80·0 (74·0 to 85·0) 79·0 (71·0 to 85·0) 7 Binocular BCVA, ETDRS 85·0 (79·0 to 88·0) 84·0 (79·0 to 88·0) 17 Patient-reported instrument scores NEI-VFQ-25 90·9 (83·6 to 95·5) 90·3 (83·3 to 95·9) 6 EQ-5D 1·000 (0·796 to 1·000) 1·000 (0·796 to 1·000) 11 Glaucoma Utility Index 0·897 (0·791 to 0·991) 0·921 (0·791 to 1·000) 17 Data are number (%) or median (IQR). PAC=primary angle closure. PACG=primary angle-closure glaucoma. IOP=intraocular pressure. MD=mean deviation index. BCVA=best-corrected visual acuity. ETDRS=Early Treatment Diabetic Retinopathy Study. NEI-VFQ–25=National Eye Institute Visual Function Questionnaire-25. EQ-5D=European Quality of Life-5 Dimensions questionnaire. Table 1: Baseline characteristics Articles www.thelancet.com Vol 388 October 1, 2016 1393 Non-parametric bootstrapping was used to generate 95% CIs for the estimated diff erences in mean costs and QALYs, and to ascertain the probability of the ICER for the clear-lens extraction approach being cost-eff ective at diff erent ceiling ratios. In accordance with the guidance of the National Institute for Health and Care Excellence, 28 we report these probabilities at ceiling ratios of £20 000 and £30 000 per QALY gained to represent decision makers’ maximum willingness to pay per QALY gained. All analyses were also repeated with a multiple imputation dataset (n=20) generated with the use of chained equations to deal with missing cost and utility data. 29 Analyses were done with Stata version 12. This study is registered with the ISRCTN registry, number ISRCTN44464607. tải về 315.39 Kb. Chia sẻ với bạn bè của bạn:
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