Nguyen hai nam, Ph. D. Associate Professor



tải về 98.57 Kb.
Chuyển đổi dữ liệu19.08.2016
Kích98.57 Kb.



    NGUYEN HAI NAM, Ph.D.

    Associate Professor

    Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi, Vietnam. Tel.: 84-4-9330351 Fax: 84-4-9332332. E.mail: nhnam@hotmail.com, doctornam@gmail.com



Current Appointments (Công tác hiện nay)

Chair, Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, Hanoi, Vietnam. 8/2008-present

Academic Education (Quá trình đào tạo)

Ph.D. Medicinal Chemistry, Chungnam National University, Korea. Feb. 2002.


M.S. Medicinal Chemistry, Chungnam National University, Korea. Feb. 1999.

B.S. Hanoi College of Pharmacy, Vietnam. Aug. 1995.

Diploma Hanoi Foreign Languages University, Vietnam. Aug. 1990.

Scientific Services (Các hoạt động khoa học khác)

  • Member of the Editorial Board, Tap chi Duoc hoc (J. Pharm. (Hanoi)) 01/2006-present

  • Member, Pharmaceutical Chemistry Section, Vietnamese Pharmacopeia IV

02/2005-present

  • Executive Guest Editor, Current Pharmaceutical Design (USA) 08/2003-present

  • Member of the Advisory Board, Recent Patents Review on CNS Agents (USA)

03/2005-present

  • Member of the Editorial Board, Revue Pharmaceutique (Hanoi) 11/2004-present

  • Regular Reviewer, Pharmacology, Biochemistry and Behavior 05/2005-present

  • Regular Reviewer, American Journal of Cancer (USA) 04/2003-present

  • Regular Reviewer, Bioorganic & Medicinal Chemistry 05/2003-present

  • Regular Reviewer, Bioorganic & Medicinal Chemistry Letters 04/2002-present


Research Experience (Kinh nghiệm nghiên cứu)

Postdoctoral Associate, Department of Biomedical Sciences and Department of Biochemistry and Molecular Cell Biology, University of Rhode Island, Rhode Island, USA. 3/2002-3/2004

  • Designed and synthesized a series of bisubstrate inhibitors of Src tyrosine kinase.

  • Designed and synthesized artificial receptors for phosphoproteins.

  • Designed and synthesized bifunctional antifungal agents.

Research Associate, Bioorganic and Medicinal Chemistry Division, Korea Research Institute of Chemical Technology, Korea. 11/2001-2/2002

  • Synthesized N-(6-aminobenzopyranyl)-N'-benzyl-N' '-cyanoguanidine analogues novel anti-ischemic ATP-sensitive potassium channel (K(ATP)) openers without vasorelaxation.

Research Graduate, Medicinal Chemistry Lab., College of Pharmacy, Chungnam Natl. Univ., Korea.

11/1996-12/2001

  • Synthesized a new class of anthracycline analogues as anticancer agents. Discovered a clinical candidate DHAQ-97.

  • Synthesized a novel series of angiogenesis inhibitors as anticancer agents.

Adjunct Research Graduate, Bioevaluation Division, Korea Institute of Bioscience and Biotechnology, Korea. 11/1999-12/2001

  • Evaluated synthetic compounds for antiangiogenic, cytotoxic, and antitumor activities in in vitro and in vivo models.

Research Undergraduate, Pharmacognosy Lab., College of Pharmacy, Hanoi, Vietnam and Center for Education and Development of Chromatography of Vietnam (EDC Vietnam).

06/1991-08/1995

  • Isolated and determined the composition of essential oil from Cinnamomum camphora.


Past Employment (Cơ quan công tác cũ)

Procter and Gamble Vietnam, Hanoi manager (8/1995-11/1996).


Memberships (Thành viên các Hiệp hội)

  • Vietnamese Chemical Society (VCS) 04/2004-present

  • American Association for Cancer Research (AACS). 04/2000-4/2002

  • American Chemical Society (ACS). 03/2002-5/2004

  • Korean Pharmaceutical Society (KPS). 06/1997-2/2002


Current & Complete Research Projects (Các đề tài đã và đang thực hiện)

  • Design, Synthesis and Bioevaluation of Novel Histone Deacetylase Inhibitors. Nafosted, Bộ Khoa học công nghệ và Môi tr­ường (NAFOSTED, Ministry of Science and Technology, Vietnam), 2010-2013. Ongoing.

  • Design, Synthesis and Bioevaluation of Benzothiazole Derivatives. Nafosted, Bộ Khoa học công nghệ và Môi tr­ường (NAFOSTED, Ministry of Science and Technology, Vietnam), 2009-2011, completed.

  • Synthesis of terazosin. Hanoi Department of Science and Technology, 2009-2010, Completed.

  • Phân lập các chất ức chế NF-kB từ cây cỏ Việt Nam (Isolation and structural elucidation of NF-kB inhibitors from Vietnamese medicinal plants). Đề tài nghiên cứu cơ bản, Bộ Khoa học công nghệ và Môi tr­ường (Basic research program, Ministry of Science and Technology, Vietnam), Completed.

  • Triển khai quy trình tổng hợp thuốc điều trị phì đại tiền liệt tuyến finasterid (Implementation of the synthesis of finasteride). Đề tài cấp bộ, Bộ Y tế. Ministry of Health of Vietnam, Completed.

  • Phân lập và xác định hàm lượng resveratrol trong cốt khí củ trồng ở Việt nam (Isolation and quantification of resveratrol in Polygonum cuspidatum). Đề tài cấp trường, Đại Học Dược Hà Nội. Hanoi University of Pharmacy.

  • Phân lập các alkaloid độc từ cây lá ngón (Study on the toxic alkaloidal composition of Gelsemium elegans Benth. growing in Vietnam) (Co-investigator, 6/2005- present). Isolation of toxic alkaloids from Gelsemium elegans Benth. growing in Vietnam. Đề tài cấp bộ, Bộ Y tế. Ministry of Health of Vietnam.

  • Development of Antimycotic Agents (Research associate, 3/2002-2004): Design and synthesis of novel prodrugs of azole antimycotic drugs (University of Rhode Island, USA). COMPLETED.

  • Development of Src SH2 Inhibitors (Research associate, 3/2002-2004): Design and synthesis of novel SH2 antagonist and Src inhibitors for possible use as biological tools and treatment of cancer and osteoporosis (University of Rhode Island, USA). COMPLETED.

  • Development of Anticancer Anthracycline Derivatives (Research assisstant, 11/1996-1/2000): Design and synthesis of 2-substituted 1,4-dihydroxy-9,10-anthraquinones and 2-substituted anthracene-1,4,9,10-tetraones as anticancer agents (Chungnam National University, Korea). COMPLETED.

  • Development of Antiangiogenic Anticancer Agents from Medicinal Plants (Research assistant, 2/1999-11/2001): Screening medicinal plants for antiangiogenic activity, isolation of active principles, totally synthesized the lead compounds and their derivatives to establish structure-activity relationships and to find more potent anticancer drug candidates (Chungnam National University, Korea). COMPLETED.

  • Study on the Composition of Essential Oil from Cinnamomum camphora L. (Research assistant, 3/1992-6/1995): Study on the content and accumulation of the essential oil from the plant C. camphora growing in Vietnam. Selection of species with high content of camphor for ecological and pharmaceutical purposes (Hanoi College of Pharmacy). COMPLETED.


Research Interests

  • Application of modern technologies and methodologies in drug discovery, such as combinatorial chemistry, high through-put screening with focus on rational drug design, target-based drug discovery.

  • Bioactive natural products (isolation and structure determination) as valuable leads for drug discovery and design.

  • Structural modification and structure-activity relationship studies on currently available leads.

  • Target activities of interest: antitumor agents, antibacterial, antiviral agents, anti-inflammatory agents.


Awards and Honors

  • Graduate Scholarships, awarded by Chungnam Natl. Univ., Korea (1997-2001).

  • Special Scholarship awarded by PetroPharma Company of Singapore (1995) for outstanding academic achievements.

  • Hanoi College of Pharmacys awards (5) for excellent achievements in study and students activities (1991~1995).

  • Vietnam Student Unions awards (3) for excellent achievements in study and students activities (1993~1995).

  • Hanois outstanding people tittle (1993).


Publications (Các công trình khoa học)

Editorial (Biên tập)


  1. Nam NH. Recent Advances in Antimitotic Agents. (Editorial). Curr. Pharm. Design. 11(13), 1593-1594, 2005.

Books and chapters (Sách và chương sách)

1. Structure-activity relationships of drug groups (in Vietnamese). To be published in 2011.

2. New drug discovery and development. Hanoi University of Pharmacy. 2010.

2. Nguyễn Tường Vy, Nguyễn Hải Nam, Dương Ly Hương, Đào Thị Kim Oanh (CB: Nguyễn Tường Vy). Thực tập Hóa trị liệu (Tài liệu dùng cho hệ trung cấp). Trường Đại Học Dược Hà Nội, 2006.


2. Võ Thị Nhị Hà, Nguyễn Hải Nam, Đào Thị Kim Oanh, Thái Duy Thìn, Nguyễn Tường Vy (CB: Thái Duy Thìn). Thực tập Hóa Dược (Tài liệu dành cho hệ dài hạn, chính quy). Trường Đại Học Dược Hà Nội, 2005.

Patents (Bản quyền)


1. Han SB, Hong JT, Kim HM, Oanh DTK, Hue VT, Nam NH. Novel Hydroxamic Acids Having Histone Deacetylase Inhibiting Activity and Pharmaceutical Composition for Treating Cancer Comprising the Same As Active Ingredient. Korean Patent No. 10-2011-0050864 (Số nhận hồ sơ: 1-1-2011-0400113-05).

2. Parang K, Sardari S, Nam NH. Preparation of azole monosaccharide as antifungal agents. PCT Int. Appl. 006860 2005, 62 pp.

3. Parang, K.; Sun, G.; Kumar, A.; Nguyen, N. H.; Wang, Y.-H.; Ye, G. Bisubstrate inhibitors of protein tyrosine kinases as therapeutic agents. PCT Int. Appl. WO 117932 (2005), 74 pp.

4. Ahn BZ, Kim Y, Kim SB, Nam NH. 5-Membered ring heterocycle (Z)-diarylethene as anticancer agents. Korean Patent No 10-2001-0018596 (2001.04.09).



5. Ahn BZ, Nam NH. 1,4-Dihydroxybenzenes: Preparation Methods and Antitumor Activity. Korean Patent No 10-2001-0074621 (2001.11.28).
Papers (Công trình khoa học)

  1. Nguyen-Hai Nam, Dao Thi Kim Oanh, Hoang Van Hai, Van Thi My Hue, Byung-Woo Han, Sang-Bae Han. Benzothiazole-containing hydroxamic acids as histone deacetylase inhibitors and antitumor agents. Bioorganic and Medicinal Chemistry Letters. 2011.

  2. Nguyễn Thị Kiều Anh, Ngô Quang Trung, Nguyễn Thị Huyền, Trần Thúy Hạnh, Nguyễn Hải Nam. Đánh giá chất lượng nguyên liệu terazosin HCl tổng hợp tại Việt Nam. Tạp chí Nghiên cứu Dược. 2011.

  3. Đào Thị Kim Oanh, Sang-Bae Han, Hoàng Văn Hải, Trần Văn Nam,Văn Thị Mỹ Huệ, Nguyễn Hải Nam. Tổng hợp N1-(benzo[d]thiazol-2-yl)-N8-hydroxyoctanamid và dẫn chất hướng ức chế histon deacetylase. Tạp chí Dược học (J Pharm Sci), 2011. (J Pharm Sci 23)

  4. Đào Thị Kim Oanh, Sang-Bae Han, Hoàng Văn Hải, Trần Văn Nam,Văn Thị Mỹ Huệ, Nguyễn Hải Nam. Tổng hợp N1-(benzo[d]thiazol-2-yl)-N6-hydroxyadipamid và dẫn chất hướng ức chế histon deacetylase. Tạp chí Dược học (J Pharm Sci), 2011. (J Pharm Sci 22)

  5. Đào Thị Kim Oanh, Sang-Bae Han, Nguyễn Hải Nam. Tổng hợp N1-(benzo[d]thiazol-2-yl)-N4-hydroxysuccinamid và dẫn chất hướng ức chế histon deacetylase. Tạp chí Dược học (J Pharm Sci), 2011. (J Pharm Sci 19)

  6. Nam NH, Dung PTP, Han SB. Synthesis and biological activity of some N-(6-substitutedbenzothiazol-2-yl)acrylamides. Med. Chem. 2011.

  7. Nam NH, Thao TP, Ngoc NA, Han SB. Synthesis and antitumor activity of some indirubins and carbaindirubins. T¹p chÝ D­îc häc (J Pharm Sci), 2011. (J Pharm Sci 21)

  8. Nam NH, Oanh DTK. Nghiªn cøu tæng hîp haloperidol decanoat. Tạp chí Hóa học (Journal of Chemistry), 2011.

  9. Thu NB, Tuan DT, Hien TT, Khoi NM, Dung TT, Quan L, Anh LTV, Nam NH. Synergistic effect of estrogen activity and phosphorylation in human breast carcinoma MCF-7 cells by methanol extracts from cortex of Vigna radiate and stem bark of Eucomia ulmoides. Scientia Pharmaceutica. 2011.

  10. Nam NH, Ngọc NA, Ahn BZ. Synthesis of (6,7-dimethoxy-2-oxo-2H-chromen-4-yl)methyl 3-arylacrylate as water soluble antitumor agents. Letters in Drug Design and Discovery 2011. (published)

  11. Nam NH, Dung PT, Thuong PT. Synthesis and Biological Evaluation of A Series of 2-(Substitutedphenyl)benzothiazoles. Medicinal Chemistry 2010. (published)

  12. Vung NT, You YJ, Nam NH. Isolation of some bioactive components from Rubia cordifolia. J. Materia Medica. (Hanoi), 15(3), 175-178, 2010. (published)

  13. Nam NH, Dung PTP. Tổng hợp và thử tác dụng sinh học của các dẫn chất benzothiazol. Phần 7. N-(Benzothiazol-2-yl)-4-nitrobezensulfonamid và dẫn chất. Tạp chí Dược học (J Pharm Sci), 2010. (published). (J Pharm Sci 17)

  14. Nam NH, Vung NT. Nghiên cứu tổng hợp terazosin hydroclorid. Tạp chí Dược học (J Pharm Sci), 50 (11), 35-39, 2010. (J Pharm Sci 18)

  15. Nam NH, Dung PTP, Hieu DT. Synthesis and Biological Evaluation of A Series of (Benzo[d]thiazol-2-yl)cyclohexanecarboxamides and (benzo[d]thiazol-2-yl)cyclohexanecarbothioamides. Med. Chem. 6 (3), 159-164, 2010.

  16. Nam NH, Ngoc NA. An improved synthesis of finasteride from 4-androsten-3,17-dione. Asian J Res. Chem. 3 (4), 1099-1102, 2010.

  17. Nam NH, Dung PTP. Tổng hợp và thử tác dụng sinh học của dẫn chất benzothiazol. Phần 5. Các (benzothiazol-2-yl)-4-morpholincarboxamid và 2-(benzoylamino)-6-ethoxybenzothiazol. Tạp chí Dược học (J Pharm Sci), 50 (9), 24-28, 2010.

  18. Nam NH. Tổng hợp finasterid. Phần II. Tổng hợp finasterid từ chất trung gian 4-azaandrost-5,16-dien-17-cyano-3-on. Tạp chí Dược học 50 (1), 53-56, 2010.

  19. Nam NH, Ngoc NA. Tổng hợp finasterid. Phần I. Tổng hợp chất trung gian 4-azaandrost-5,16-dien-17-cyano-3-on. Tạp chí Dược học (J Pharm Sci), 49 (10), 31-34, 2009.

  20. Nam NH, Thao TP, Dung PTP. Synthesis and biological activities of some benzothiazole derivatives. The Sixth Indochina Conference on Pharmaceutical Sciences. Hue, Vietnam, 11-18/12/2009. pp. 172-177.

  21. Nam NH, You YJ. NF-B inhibitory activities of the methanol extracts and some constituents therein of some Vietnamese medicinal plants. Scientica Pharmaceutica 77, 389-399, 2009.

  22. Nam NH. Tổng hợp và độc tính tế bào của một số dẫn chất 2,3-diarylpropenal (Synthesis and cytotoxicity of some 2,3-diarylpropenals). Tạp chí Dược học (J Pharm Sci), 7, 49-552, 2009.

  23. Nam NH, Dung PTP, Thao TP. Tổng hợp và tác dụng sinh học của dẫn chất benzothiazol. Phần 3: C¸c 2-phenylbenzothiazol. Tạp chí Dược học (J Pharm Sci), 5, 43-47, 2009.

  24. Nam NH, Dung PTP, Huong NC. Tổng hợp và tác dụng sinh học của dẫn chất benzothiazol. Phần 2: C¸c benzothiazol-2-yl-cyclopropylcarboxamid. Tạp chí Dược học (J Pharm Sci), 2, 29-33, 2009.

  25. Nam NH, Dung PTP, Oanh DTK, Thao TP, Ngoc NA. Tổng hợp và tác dụng sinh học của dẫn chất benzothiazol. Phần 1: C¸c 2-acylaminobenzothiazol. Tạp chí Dược học (J Pharm Sci). 12, 31-35, 2008.

  26. Nam NH, Ngoc NA, Tuat CT. Tổng hợp và tác dụng kháng nấm của một số dẫn chất O-acylfluconazol. Tạp chí Dược học (J. Pharm. Sci.) 6, 20-23, 2008.

  27. Nam NH, Vung NT. Isolation of some bioactive compounds from Perilla ocymoides. J. Materia Medica. 13(3), 120-123, 2008.

  28. Nam NH, Ngoc NA, Son BN. Tổng hợp và tác dụng sinh học của một số dẫn chất ester có khả năng tác dụng kéo dài của artemisinin. Tạp chí Dược học (J. Pharm. Sci.), 4, 26-28, 2008.

  29. Nam NH, et al. Synthesis and cytotoxicity of derivatives of 4’,5,6-trihydroxy-3,3’,7-trimethoxyflavone isolated from Miliusa balansae. VAST Proceedings of the International Scientific Conference on Chemistry for Development and Integration. Hà Nội, 12/2008, trang 171-178.

  30. Tuan ND, Nam NH, Vung NT. Định lượng resveratrol trong cốt khí củ trồng ở Việt Nam. Tạp chí Dược học (J Pharm Sci), 11, 13-16, 2007.

  31. Ye G, Nam NH, Kumar A, Saleh A, Shenoy DB, Amiji MM, Lin X, Sun G, Parang K. Synthesis and Evaluation of Tripodal Peptide Analogues for Cellular Delivery of Phosphopeptides. J. Med. Chem. 50, 3604-3617, 2007.

  32. Nam NH, Ahn BZ. Combretastatin-Chalcone hydrids: Synthesis and cytotoxicity. Med. Chem. 3, 373-377, 2007.

  33. Nam NH, You YJ, Vung NT. NF-kB inhibitory activity of some medicinal plants extracts. Journal of Materia Medica, 12(2), 43-46, 2007.

  34. Nam NH, Chung LH. Phân lập resveratrol và emodin từ cốt khí củ trồng ở Việt Nam. Tạp chí Dược học (J. Pharm. Sci.) 1, 7-10, 2007.

  35. Nam NH, Ngoc NA, Ye G, Parang K. Design and synthesis of conformational constrained Src SH2 domain inhibitors. The Fifth Indochina Conference on Pharmaceutical Sciences. Bangkok, 11/2007. p. 164.

  36. Nam NH, Ngoc NA, Tuat CT. Tổng hợp và thử tác dụng sinh học của các dẫn chất O-acylfluconazol. Tuyển tập các công trình Hội nghị khoa học và công nghệ hóa học hữu cơ toàn quốc lần thứ tư, Hà Nội, 10/2007, trang 159-164.

  37. Nam NH. Tác dụng chống ung thư in vitroin vivo của phức hợp camptothecin-clorambucil. (Cytotoxicity and antitumor activity of the camptothecin-chlorambucil hybrid). Tạp chí Dược học (J. Pharm. Sci.). 8, 19-20, 2006.

  38. Hien TT, Nam NH, Hue BT, Son DC. Xây dựng phương pháp HPLC kiểm nghiệm chế phẩm chứa nevirapin. Tạp chí Kiểm nghiệm 4(12), 4-7, 2006.

  39. Nam NH. Naturally Occuring NF-kB Inhibitors. Mini-Review in Medicinal Chemistry 6, 945-951, 2006.

  40. Nam NH, Cuong NM. Alpha-Substituted 2,5-Dihydroxychalcones: Synthesis and Cytotoxicity. J. Chem. 42(2), 239-244, 2006.

  41. Nam NH. Nghiên cứu tổng hợp resveratrol (Synthesis of resveratrol). Tạp chí Dược học (J. Pharm. Sci.) 6, 9-11, 2006.

  42. Nam NH, Vung NT. Phân lập và xác định cấu trúc của hai flavanoid từ Crinum latifolium (Isolation and Structural Elucidation of Two Flavanoids from Crinum latifolium). Tạp chí Dược học (J. Pharm. Sci.) 1, 7-9, 2006.

  43. Nam NH. Artemisinin Derivatives as Antimalarial and Antitumor Agents. Revue Pharmaceutique 26(2), 3-11, 2005.

  44. Nam NH and Vung NT. Antioxidant Activity of Some Synthetic Chalcones. J. Materia Medica. 10, 80-83, 2005.

  45. Nam NH. Convenient synthesis of [bis(2-acyloxyethyl)-amino]-acetic acid. Application in the synthesis of camptothecin-chlorambucil hybrid as an antitumor agent). Tạp chí Dược học (J. Pharm. Sci.). 7, 7-10, 2005.

  46. Ye G, Ayrapetov M, Nam NH, Sun G, Parang K. Solid-phase binding assays of peptides using EGFP-Src SH2 domain fusion protein and biotinylated Src SH2 domain. Bioorg. Med. Chem. Lett. 15, 4994-4997, 2005.

  47. Nam NH. Tổng hợp một số phức hợp hướng đại tràng của thuốc chống viêm corticoid 1. Synthesis. Revue de Pharmaceutique. 26(1), 17-24, 2005.

  48. Ayrapetov MK, Nam NH, Ye G, Kumar A, Parang K, Sun G. Functional diversity of CSK, CHK and SRC SH2 domains due to a single residue variation. J Biol Chem. 280, 25780-25787, 2005.

  49. Nam NH. Nghiên cứu tổng hợp và thử tác dụng sinh học của một số dẫn chất của fluconazol. (Synthesis and biological activity of some fluconazole derivatives). Tạp chí Dược học (J. Pharm. Sci.). 5, 13-15, 2005.

  50. Min BS, Huong HT, Kim JH, Jun HJ, Na MK, Nam NH, Lee HK, Bae K, Kang SS. Furo-1,2-naphthoquinones from Crataegus pinnatifida with ICAM-1 Expression Inhibition Activity. Planta Medica 70, 1166-1170, 2004.

  51. Nam NH, You YJ, Kim Y, Hong DH, Kim HM, Ahn BZ. New Contituents from Crinum latifolium with Inhibitory Activity against Tube-like Formation of Human Umbilical Endothelial Cells. Nat. Prod. Res. 18, 485-491, 2004.

  52. Nam NH, Sardari S, Selecky M, Parang K. Carboxylic acid and phosphate ester derivatives of fluconazole: synthesis and antifungal activities. Bioorg. Med. Chem. 12, 6255-6269, 2004.

  53. Nam NH, Lee S, Ye G, Sun G, Parang K. ATP-Phosphopeptide Conjugates as Inhibitors of Src Tyrosine Kinases. Bioorg. Med. Chem. 12, 5753-5766, 2004.

  54. Huong DTT, Sung TV, Nam NH, Ahn BZ. Tổng hợp và hoạt tính của một số dẫn xuất của 4,5,6-trihydroxy-3,3,7-trimethoxyflavon được phân lập từ cây Milliusa balansae. (Synthesis and Cytotoxic Activities of Some Derivatives of 4',5, 6- trihydroxy-3,3',7-trimethoxyflavone isolated from Miliusa balansae). J. Chem. 42(1), 57-60, 2004.

  55. Nam NH, Hong DH, You YJ, Kim Y, Kim HM, Ahn BZ. Synthesis and Cytotoxicity of 2,5-Dihydroxychalcones and Related Compounds. Arch. Pharm. Res. 27, 581-588, 2004.

  56. Nam NH, Sardari S, Sun G, Parang K. Novel Cyclic SH2 Domains Inhibitors: Design, Synthesis and Binding Modes. J. Med. Chem. 47, 3131-3141, 2004.

  57. Nam NH, Rebecca P, Sun G, Sardari S, Tiemo A, Xie M, Yan B, Parang K. Design of Tetrapeptide Ligands as Inhibitors of the Src SH2 Domain. Bioorg. Med. Chem. 12, 779-787, 2004.

  58. You YJ, Kim Y, Nam NH, Ahn BZ. Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity. Eur. J. Med. Chem. 39, 189-193, 2004.

  59. Nam NH, Vung NT. Novel Chemotherapeutics for Cancer Treatment. Revue Medicine de Hanoi, 1, 17-27, 2004.

  60. Nam NH, Vung NT. Cell Cycle and Apoptosis in Anticancer Drug Development. Revue Medicine, 1, 54-61, 2004.

  61. Nam NH, Parang K. Current Targets for Anticancer Drug Discovery. Current Drug Targets 4, 159-179, 2003.

  62. Lee S, Lin X, Nam NH, Parang K, Sun G. Determination of a Substrate-Docking Site of Protein Tyrosine Kinase Csk. Proc. Natl. Acad. Sci. USA. 100, 14707-14712, 2003.

  63. Nam NH, Sardari S, Parang K. Reactions of Solid-Supported Reagents and Solid Supports with Alcohols and Phenols through Their Hydroxyl Functional Group. J. Comb. Chem. 5, 479-546, 2003.

  64. Nam NH. Combretastatin A-4 Analogues as a Class of Antimitotic Anticancer Agents. Curr. Med. Chem. 10, 1697-1722, 2003.

  65. Sardari S, Pourmorad F, Tiemo A, Nam NH, Parang K. Protein Kinases and Their Modulation in the Central Nervous System. Curr. Med. Chem. CNS Agents. 3, 341-364, 2003.

  66. Nam NH, Kim Y, You YJ, Hong DH, Kim HM, Ahn BZ. Water Soluble Prodrugs of the Antitumor Agent 3-[3-(Amino-4-methoxy)phenyl]-2-(3,4,5-trimethoxyphenyl)cyclopent-2-ene-1-one. Bioorg. Med. Chem. 11(6), 1021-1029, 2003.

  67. Nam NH, Kim Y, You YJ, Hong DH, Kim HM, Ahn BZ. Cytotoxic 2,5-dihydroxychalcones with unexpected antiangiogenic activity. Eur. J. Med. Chem. 38(2), 179-187 2003.

  68. You YJ, Kim Y, Nam NH, Ahn BZ. Unsaturated Fatty Acid Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin. Bioorg. Med. Chem. Lett. 13, 2629-2632, 2003.

  69. You YJ, Kim Y, Nam NH, Ahn BZ. Synthesis and cytotoxicity of A-ring modified betulinic acid derivatives. Bioorg. Med. Chem. Lett. 13, 3137-3140, 2003.

  70. Nam NH, Lee CW, Hong DH, Kim HM, Bae KH, Ahn BZ. Antitumor, Antiangiogenic and Antiinvasive Activity of the Ephedra sinica Extract. Phytother. Res. 17, 70-76, 2003.

  71. Nam NH, Kim HM, Bae KH, Ahn BZ. Antiangiogenic activity of Vietnamese medicinal plants. Phytother. Res. 17, 107-111, 2003.

  72. You YJ, Nam NH, Kim Y, Bae KH, Ahn BZ. Antiangiogenic Lupeol from Bombax ceiba. Phytother. Res. 17, 341-344, 2003.

  73. You YJ, Kim Y, Nam NH, Ahn BZ. Antiangiogenic cardenolides from Adonis amurensis. Phytother. Res. 17, 568-570, 2003.

  74. Huong DTT, Kamperdick C, Van NH, Sung TS, Nam NH, Ahn BZ. Antiangiogenic activity of constituents from Miliusa balansae. J. Materia Medica. 8(4), 107-110, 2003.

  75. Nam NH, Vung NT. Protein Kinases as Targets for Anticancer Drug Discovery. Revue Medicine, 1&2, 1-11, 2002.

  76. Nam NH, Vung NT. Current Antiangiogenic Anticancer Drug Discovery. Revue Pharmaceutique, 1&2, 5-15, 2002.

  77. Nam NH, Kim Y, You YJ, Hong DH, Kim HM, Ahn BZ. Synthesis, cytotoxicity and antitumor activity of 2,3-diarylcyclopent-2-ene-1-ones. Arch. Pharm. Res. 25, 600-607, 2002.

  78. Nam NH, Kim Y, You YJ, Hong DH, Kim HM, Ahn BZ. Synthesis and cytotoxicity of some rigid derivatives of methyl 2,5-dihydroxycinnamate. Arch. Pharm. Res. 25, 590-599, 2002.

  79. Kim Y, You YJ, Nam NH, Ahn BZ. Prodrugs of 4-Demethyl-4-deoxypodophyllotoxin: Synthesis and Evaluation of Antitumor Activity. Bioorg. Med. Chem. Lett. 12, 3435-3438, 2002.

  80. Nam NH, Kim Y, You YJ, Hong DH, Kim HM, Ahn BZ. Preliminary structure-activity relationships of the novel angiogenesis inhibitor 4-senecioyloxymethyl-6,7-dimethoxycoumarin. Bioorg. Med. Chem. Lett. 12, 2345-2348, 2002.

  81. Nam NH, Ahn BZ. Synthesis and Antitumor Activity of Rigid 2,5-Dihydroxycinnamates. J. Chemistry 40(3), 111-115, 2002.

  82. Kim Y, Nam NH, You YJ, Ahn BZ. Diaryl-2(5H)-furanone: Syntheses and evaluation of cytotoxicity. Bioorg. Med. Chem. Lett. 12, 719-722, 2002.

  83. Nam NH, Kim Y, You YJ, Hong DH, Kim HM, Ahn BZ. Synthesis and Antitumor Activity of Novel Combretastatins: Combretocyclopentenones and Related Analogues. Bioorg. Med. Chem. Lett. 12, 1955-1958, 2002.

  84. Kim Y, You YJ, Nam NH, Ahn BZ. 2,3-Dibenzylbutyrolactones and 1,2,3,4-tetrahydro-2-naphthoic acid gamma-lactones: structure and activity relationship in cytotoxic activity. Arch. Pharm. Res. 25, 240-249, 2002.

  85. You YJ, Kim Y, Nam NH, Ahn BZ. Lupane derivatives II. Synthesis and cytotoxicity. Yakhak Hoeji (Kor. J. Pharm.) 46, 301-306, 2002.

  86. Nam NH, Vung NT, Khanh TC. Ceiba pentandra A new medicinal plant with potential use as an antitumor remedy. J. Materia Medica 7(6), 186-189, 2002.

  87. Nam NH. Monoamine oxidase inhibitory activity of chemical constituents from Notopterygium incisium. J. Materia Medica 7(2), 54-56, 2002.

  88. Cuong NM, Nam NH, Kim Y, You YJ, Bae KH, Sung TV, Ahn BZ. Cytototoxic Activity of Vietnamese Herbal Drugs against A549 Cells. Kor. J. Pharmacognosy 33, 64-68, 2002.

  89. Huong DT, Sung TV, Nam NH, Ahn BZ. Tổng hợp các dẫn xuất của một flavon thiên nhiên được chiết từ cây Milliusa balansae. (Synthesis of derivatives from a natural flavone isolated from Milliusa balansae). Tuyển tập các kết quả nghiên cứu khoa học viện hóa học năm 2001, trang 239-243. (Collection of Scientific Research of the Institute of Chemistry, 2001, p. 239-243).

  90. Jin GZ, You YJ, Kim Y, Song GY, Nam NH, Ahn BZ. Esters of Chlorambucil as Multifunctional Anticancer Agents. Eur. J. Med. Chem. 36, 361-366, 2001.

  91. Nam NH, You YJ, Kim Y, Hong DH, Kim HM, Ahn BZ. Syntheses of Certain 3-Aryl-2-propenoates and Evaluation of their Cytotoxicity. Bioorg. Med. Chem. Lett. 11, 1173-1176, 2001.

  92. Nam NH, Kim Y, You YJ, Hong DH, Kim HM, Ahn BZ. Combretoxazolones: Syntheses and biological activity. Bioorg. Med. Chem. Lett. 11, 3073-3076, 2001.

  93. Nam NH, Huong HTT, Tam MN, Khanh TC. Monoamine oxidase inhibitory activity of herbal drugs. J. Materia Medica 6(1), 22-25, 2001.

  94. Tam MN, Nam NH, Jin GZ, Song GY, Ahn BZ. Synthesis and Evaluation of Antitumor Activity of 2-Substituted-1,4-dihydroxy-9,10-anthraquinones. Arch. Pharm. Pharm. Med. Chem. 333, 189-194, 2000.

  95. Tam MN, Nam NH, Jin GZ, Ahn BZ. 2-(1-Oxyiminoalkyl)-1,4-dimethoxy-9,10-anthraquinones: Synthesis and Evaluation of Cytotoxicity. Arch. Pharm. Res. 23, 283-287, 2000.

  96. Nam NH, Huong HTT, Kim HM, Ahn BZ. Cytotoxic Constituents from Notopterygium incisum. Kor. J. Pharmacognosy 31, 77-81, 2000.

  97. Nam NH, Huong HTT, Tam MN, Khanh TC. Cytotoxicity of Herbal Drugs against B16 Melanoma Cell Line. J. Materia Medica 5(1), 16-20, 2000.

  98. Nam NH. A Cytotoxic principle from Siegesbeckia orientalis growing in Vietnam. J. Chemistry 38 (4), 84-86, 2000.

  99. Nam NH, Jin GZ, Tam MN, Ahn BZ. Effect of the aryl groups on the cytotoxicity and antitumor activity of 2-substituted-1,4-dihydroxy-9,10-anthraquinones and 2-substituted-anthracene-1,4,9,10-tetraones. Arch. Pharm. Res. 22, 592-607, 1999.

  100. Viet DQ, Dien PG, Tam MN, Phi PTP, Nam NH, You YJ, Ahn BZ. Cytotoxicity of some anthraquinones from the stem of Morinda citrifolia growing in Vietnam. J. Chemistry 37(3), 84-87, 1999.


Presentations at Conferences (Báo cáo tại các Hội nghị)

  1. Nam NH, Khien PV. A contribution to the study of the plant Cinnamomum camphora L., Lauraceae from Vietnam. The 17th National Youth Scientific Conference in Pharmacy and Medicine. May 19, 1994, Hanoi, Vietnam.

  2. Nam NH, Jin GZ, Ahn BZ. Effect of the aryl groups on the cytotoxicity and antitumor activity of 2-substituted-1,4-dihydroxy-9,10-anthraquinones and 2-substituted-anthracene-1,4,9,10-tetraones. The 47th Annual Convention of the Pharmaceutical Society. October 23-24, 1998, Suwon, Korea.

  3. Tam MN, Jin GZ, Nam NH, Ahn BZ. 2-(1-Oxyiminoalkyl)-1,4-dihydroxyanthracene-9,10-diones: Synthesis and Evaluation of Antitumor Activity. The 47th Annual Convention of the Korean Pharmaceutical Society. October 23-24, 1998, Suwon, Korea.

  4. Ahn BZ Nam NH, Kim Y, You YJ, Kim SH, Kim HM. Inhibitory Effects on Human Umbilical Vein Endothelial Cells of Constituents from Vietnamese and Korean Medicinal Plants. 91st Annual Convention of American Association for Cancer Research, April 1-5, 2000, San Francisco, USA.

  5. Nam NH, Kim HM, Ahn BZ. Cytotoxic Constituents from Notopterygium Incisum. Spring Convention of the Korean Pharmaceutical Society. April 20-21, 2000, Pusan, Korea.

  6. Nam NH, Lee CW, Kim HM, Ahn BZ. Antitumor, Antiangiogenic and Antiinvasive Activity of the Ephedra Sinica Extract. Spring Convention of the Korean Pharmaceutical Society. April 20-21, 2000, Pusan, Korea.

  7. Nam NH, Lee CW, Hong DH, Bae KH, Kim HM, Ahn BZ. Antiangiogenic activity of Vienamese medicinal plants. The 49th Annual Convention of the Korean Pharmaceutical Society. October 19-20, 2000, Seoul, Korea.

  8. Nam NH, You YJ, Kim Y, Hong DH, Kim HM, Ahn BZ. Synthesis and Cytotoxicity of Certain 3-Aryl-2-propenoates. Spring Convention of the Korean Pharmaceutical Society. April 19-20, 2001, KwangJu, Korea.

  9. Kim Y, Nam NH, You YJ, Ahn BZ. Synthesis and Cytotoxicity of 3,4-Diaryl-2(5H)-Furanone Derivatives. The 50th Annual Convention of the Korean Pharmaceutical Society. October 17-19, 2001, Seoul, Korea.

  10. Kim Y, You YJ, Nam NH, Ahn BZ. Synthesis and Antitumor Activity of 4-O-Aminoacyl-carbamate-, and carbonate prodrugs of 4-Demethyl-1-Deoxypodophyllotoxin. The 50th Annual Convention of the Korean Pharmaceutical Society. October 17-19, 2001, Seoul, Korea.

  11. Nam NH, Kim Y, You YJ, Bang SC, Hong DH, Kim HM, Ahn BZ. Synthesis and Biological Activity of Combretoxazolones. The 50th Annual Convention of the Korean Pharmaceutical Society. October 17-19, 2001, Seoul, Korea.

  12. You YJ, Kim Y, Nam NH, Ahn BZ. Lupane Derivative Bearing Aminoacetyl Moiety. The 50th Annual Convention of the Korean Pharmaceutical Society. October 17-19, 2001, Seoul, Korea.

  13. You YJ, Kim Y, Nam NH, Ahn BZ. Deoxypodophyllotoxin Derivatives with Potent Antitumor Activity. The 50th Annual Convention of the Korean Pharmaceutical Society. October 17-19, 2001, Seoul, Korea.

  14. Nam NH, Vung NT, Ahn BZ. New Antiangiogenic Constituents from Crinum latifolium. 3rd Indochina Pharmaceutical Conference. Bangkok, Thailand, May 13rd-19th, 2003.

  15. Ye G, Nam NH, Kumar A, Parang K. Non-covalent cellular delivery of phosphopeptides by amphipathic peptides. American Chemical Society Annual Convention, Chicago, 8, 2007.

  16. Nam NH, Sardari S, Parang K. Synthesis and antifungal activities of modified fluconazole derivatives. American Chemical Society Annual Convention, Chicago, 8, 2007.

  17. Nam NH, Ngoc NA, Tuat CT. Tổng hợp và tác dụng sinh học của một số dẫn chất O-acylfluconazol. (Synthesis and biological activity of some O-acylfluconazole derivatives). Hội nghị Hóa học toàn quốc, Hội Hóa học Việt Nam, Hà Nội, tháng 9 năm 2007.

  18. Nam NH, Ye GF, Sun G, Parang K. Design and synthesis of conformationally constrained Src SH2 domain inhibitors. 5th Indochina Conference in Pharmaceutical Sciences. Bangkok, Thailand, 21st-26th November, 2007.

  19. Thao TP, Dung PTP, Ngoc NA, Phuong TT, Hieu DT, Huong NC, Nam NH. Tổng hợp và tác dụng sinh học của một số dẫn chất benzothiazol. Hanoi University of Pharmacy Scientific Conference. January 24-25, 2008.

    Updated 15th October, 2011










Cơ sở dữ liệu được bảo vệ bởi bản quyền ©hocday.com 2019
được sử dụng cho việc quản lý

    Quê hương