CASSIA GUM
First draft prepared by
Dr S.M.F. Jeurissen,
1
Dr M. DiNovi
2
and Dr A. Mattia
2
1
Centre for Substances and Integrated Risk Assessment, National Institute
for Public Health and the Environment, Bilthoven, the Netherlands
2
Center for Food Safety and Applied Nutrition, Food and Drug Administration,
College Park, Maryland, United States of America (USA)
1. Explanation ............................................................................
1.1 Chemical and technical considerations ...........................
2. Biological data .......................................................................
2.1 Biochemical aspects ........................................................
2.2 Toxicological studies .......................................................
2.2.1 Acute toxicity ..........................................................
2.2.2 Short-term studies of toxicity ..................................
2.2.3 Long-term studies of toxicity and carcinogenicity...
2.2.4 Genotoxicity ...........................................................
2.2.5 Reproductive toxicity ..............................................
2.3 Observations in humans ..................................................
3. Dietary exposure ...................................................................
3.1 Use in foods ....................................................................
3.2 Dietary exposure estimates .............................................
4. Comments .............................................................................
4.1 Toxicological data ............................................................
4.2 Assessment of dietary exposure .....................................
5. Evaluation ..............................................................................
6. References ............................................................................
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