Syncrip facilitates porcine parvovirus viral dna replication through the alternative splicing of ns1 mrna to promote ns2 mrna formation



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Document Outline

  • SYNCRIP facilitates porcine parvovirus viral DNA replication through the alternative splicing of NS1 mRNA to promote NS2 mRNA formation
    • Abstract 
    • Introduction
    • Materials and methods
    • Results
      • PPV NS1 mRNA can specifically interact with SYNCRIP
      • PPV infection up-regulates SYNCRIP expression in vitro and in vivo
      • CRISPR-Cas9 mediated knockout of SYNCRIP impairs PPV replication
      • Over-expression of SYNCRIP leads to the reduction of NS1 mRNA and protein expression
      • SYNCRIP regulates the ratio of NS1 mRNA to NS2 mRNA and the replication of PPV
      • SYNCRIP affects the NS1 expression by acting on the 3′-terminal sites of NS2 mRNA
    • Discussion
    • Acknowledgements
    • References

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