2
On the one hand, there is difficulty in making a general statement about ISEs for water
research,
specifically in terms of whether they are suitable. This lies in the complexity and heterogeneity of
the samples. Accordingly, particular scenarios are discussed. On the other hand, it
is also evident
that further steps are still needed at the fundamental level, including development of receptors,
robust membranes and novel alternatives that would enable the sensing of ions at deep-sea.
Importantly, there is a plenty of room for
improvement and new approaches; and it should be
stressed that the recent progress in water research using ISEs has been owing to multidisciplinary
efforts. Facing this challenge is very exciting and the development of ISE platforms that enable
working in real conditions is quite plausible.
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